pentobarbital increases toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on. CYP3A4 inducers may perhaps boost the metabolism of ifosfamide to its Lively alkylating metabolites.pentobarbital will reduce the level or influence of buprenorphine subdermal implant by impacting hepatic/intestinal e